C: Use with warning if Advantages outweigh pitfalls. Animal scientific tests show danger and human scientific studies not offered or neither animal nor human scientific studies accomplished.
pentobarbital will increase effects of ifosfamide by influencing hepatic enzyme CYP2B6 metabolism. Use Caution/Watch. Coadministration of ifosfamide with CYP2B6 inducers could increase metabolism of ifosfamide to its metabolite. Check for greater effects/toxicities if put together with CYP2B6 inducers.
pentobarbital will decrease the extent or result of alfuzosin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importance Unidentified.
pentobarbital will minimize the extent or outcome of phenytoin by influencing hepatic enzyme CYP2C9/ten metabolism. Use Warning/Monitor.
pentobarbital will lessen the extent or impact of nicardipine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.
pentobarbital increases toxicity of ifosfamide by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. CYP3A4 inducers may possibly raise the metabolism of ifosfamide to its active alkylating metabolites.
Contraindicated (1)pentobarbital will lessen the extent or effect of cobimetinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Keep away from coadministration. Robust or reasonable CYP3A inducers may perhaps decrease cobimetinib systemic exposure by >80% and lessen its efficacy.
lasmiditan, pentobarbital. Either improves effects of another by sedation. Use Warning/Keep track of. Coadministration of lasmiditan as well as other CNS depressant drugs, together with alcohol haven't been evaluated in clinical scientific studies. Lasmiditan may lead to sedation, as well website as other cognitive and/or neuropsychiatric adverse reactions.
buprenorphine, prolonged-performing injection and pentobarbital both enhance sedation. Avoid or Use Alternate Drug. Limit use to sufferers for whom choice therapy selections are insufficient
Barbiturates can result in fetal harm when administered to the Expecting female; retrospective, circumstance-controlled scientific studies have proposed a link involving maternal intake of barbiturates and an increased-than-predicted incidence of fetal abnormalities
fentanyl transmucosal and pentobarbital each improve sedation. Stay away from or Use Alternate Drug. Limit use to patients for whom option therapy choices are insufficient
pentobarbital will minimize the level or result of amiodarone by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.
pentobarbital will decrease the level or influence of rolapitant by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Very long-time period coadministration of strong CYP3A4 inducers with rolapitant could substantially lessen rolapitant efficacy.
pentobarbital will lower the level or impact of ramelteon by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Importance Not known.